Immunogenicity and safety profile of a primary dose of bivalent oral polio vaccine given simultaneously with DTwP-Hb-Hib and inactivated poliovirus vaccine at the 4th visit in Indonesian infants | Vaccine.
[Open Access] [Received 12 August 2019, Revised 24 December 2019, Accepted 5 January 2020, Available online 22 January 2020] [In Press, Corrected Proof]
* Four bOPV doses and 1 IPV dose resulted in high seroprotection for P1, P2, and P3.
* Despite only had 1 dose of P2 in IPV, subjects have high seroprotection for P2.
* There was no systemic event during 30 min after birth dose of bOPV.
In this study, we aimed to evaluate the immunological protectivity of infants following four doses of bivalent oral polio vaccine (bOPV; Bio Farma), which were given simultaneously with DTwP-Hb-Hib (Pentabio®), along with one dose of inactivated poliovirus vaccine (IPV) at the fourth visit. A total of 143 newborn infants who fulfilled the inclusion criteria were enrolled and completed the study. Subjects received the first dose of bOPV at birth. On days 60, 90 and 120, bOPV was given simultaneously with Pentabio®. On day 120, one dose of IPV was also administered. Serum samples for serology analysis were collected before the first dose of bOPV (at day 0), before the second dose of bOPV (at day 60) and 30 days after the last dose of bOPV. In addition, the intensity, duration and relationship of each adverse event to the trial vaccines were assessed. Seroprotection rates after the fourth dose of bOPV were 100%, 91.6% and 99.3% for poliovirus P1, P2 and P3, respectively. Seroconversion rates after the fourth dose of bOPV were 100.0%, 93.3% and 100% for poliovirus P1, P2 and P3, respectively. There were no severe adverse events, and systemic reactions were generally mild during the 1–28 day post-vaccination period. Collectively, our findings indicate that bOPV given simultaneously with Pentabio® and one dose of IPV at the 4th visit was immunogenic and well tolerated.
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Australia: Gillian Thomas of Polio Australia receives the Medal (OAM) of the Order of Australia in the General Division | Australia Day 2020 Honours List.
Congratulations to Gillian Thomas of Polio Australia for being awarded the Medal (OAM) of the Order of Australia in the General Division in the Australia Day 2020 honours for service to community health, particularly to people with polio.
MEDAL (OAM) OF THE ORDER OF AUSTRALIA IN THE GENERAL DIVISION
Ms Gillian THOMAS, Kensington NSW 2033
For service to community health, particularly to people with polio.
- President, since 2017.
- Vice-President and Business Manager, 2012-2017.
- Inaugural President and Business Manager, 2009-2012.
- Author and Webmaster, 'Polio Australia' website, current.
Polio NSW (formerly Post-Polio Network NSW)
- President, since 1997.
- Life Member, since 2009.
- Member, Management Committee, since 1988.
- Secretary, Management Committee, 1990-1997.
- Controlling Webmaster, 'Polio NSW' website, since 1995.
- Editor of quarterly Polio Newsletter, 1989-2016.
- Member, Steering Committee involved in the formation of the organisation, 1988.
- Helped to establish, and Member of, the Federal 'Parliamentary Friends of Polio Survivors' Friendship Group, since 2010.
- Established and manages the website, 'Australian Polio Register", (information on the number of polio survivors living in Australia today), since 2010.
- Author and webmaster, www.poliohealth.org.au and www.stillhere.org.au .
- Member, Consumer Advisory Committee, Post-Polio Health International, mid-2000s.
Awards and recognition include:
- Recipient, Community Award, Australia Day Awards, for outstanding service to polio survivors and the community*, Randwick Council, 2009.
- Recipient, Inaugural David Bodian Memorial Award, International Post-Polio Task Force, 2002.
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