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Ghana: Polio vaccination under way in Tema West | GhanaWeb.

[12 September 2020]

Children under five years in all communities in the Tema West Municipality are being vaccinated against the poliomyelitis virus.

The immunisation exercise, being conducted by the Ghana Health Service in eight regions and 179 districts across the country, is expected to boost the immunity of children zero to 59 months and provide further protection against the virus.

In all, some 28, 277 children under five years in all communities in the Municipality are being targeted for immunisation which is expected to end on Sunday.

Unlike previous immunisation exercises, where schools were mostly target, this particular exercise is being conducted door-to-door since schools are closed due to the COVID-19 pandemic.

Mr Isaac Abrefa Busia, Tema West Municipal Public Health Officer, told the Ghana News Agency (GNA) that the vaccines were safe and effective for children, and called on caregivers to ensure that children under five years were immunised.

He said with a 103.8 per cent coverage in the last immunisation exercise, he hoped the current exercise would witness a high coverage in spite of the COVID-19 pandemic and fear that caregivers were likely to refuse vaccination for fear contracting the virus.

He said parents and caregivers were being sensitised as part of the campaign to ensure maximum coverage.

He explained that “the more your child receives vaccines, the more protected the child is against vaccine preventable diseases including paralysis and sometimes death.”

Mr Abrefa Busia, therefore, entreated caregivers to allow health personnel to administer the vaccines irrespective of the number of times the child may have been vaccinated.


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Over 12 million Pakistani children vaccinated under Mohamed bin Zayed Al Nahyan's Initiative for Global Polio Eradication | Gulf News.

[September 12, 2020 20:40] [WAM]

UAE polio vaccination in PAK
UAE-PAP Director Abdullah Khalifa Al Ghafli stated that the UAE Polio Campaign in Pakistan is being implemented as part of the initiative of His Highness Sheikh Mohammed bin Zayed Al Nahyan for Global Polio Eradication.Image Credit: WAM

Abu Dhabi: The UAE-Pakistan Assistance Programme, UAE PAP, announced that it has vaccinated 12,144,323 Pakistani children under five-years old against polio from 17th to 26th August, 2020, in a nationwide campaign to vaccinate 12,788,000 children as part of the Initiative of His Highness Sheikh Mohamed bin Zayed Al Nahyan for Global Polio Eradication.

UAE PAP said the second exceptional anti-polio campaign has achieved 95 percent success despite the challenge posed by the proliferation of the coronavirus, COVID-19.

UAE-PAP Director Abdullah Khalifa Al Ghafli stated that the UAE Polio Campaign in Pakistan is being implemented as part of the initiative of His Highness Sheikh Mohammed bin Zayed Al Nahyan for Global Polio Eradication.

This initiative is part of the UAE's humanitarian approach in cooperation with international organisations and institutions to provide humanitarian and health assistance to needy and poor communities and peoples, and to support global efforts to eradicate polio and reduce its incidence by a large percentage in the countries targeted by the initiative, namely the Islamic Republic of Pakistan and the Islamic Republic of Afghanistan.

The number of cases recorded this year in Pakistan has reached 68, especially in areas where children are deemed the most threatened and vulnerable to infection with the virus, he noted.

The geographical scope of the campaign included 88 of the difficult and high-risk areas in Khyber Pakhtunkhwa and Federally Administered Tribal Area, Balochistan region, Punjab region, and Sindh region, with the participation of more than 82,000 members consisting of doctors, observers and members of vaccination teams, and more than 20,000 protection and security personnel and management and coordination teams.

Al Ghafli explained that this campaign was carried out with modern methods and with high preventive standards, including training courses to qualify the teams to perform the task in light of field challenges and risks related to their protection and safety, and to ensure the safety of children targeted by vaccination from being infected by the coronavirus.

Preventive measures were directed at parents regarding sterilising their hands before vaccinating their children, and distributing free masks.

The UAE vaccination campaign began in 2014 and until August 2020 managed to administer 468,443,542 doses of vaccination against polio to more than 86 million Pakistani children.


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Nigeria: Polio Eradication: Dangote, Gates Foundation commends Yobe state | Vanguard Newspapers.

[SEPTEMBER 12, 2020 7:50 PM]

Bill and Melinda Gates and Dangote Foundations have commended Yobe Government for its commitment to fighting the wild polio virus in the state.

The information is contained in a statement signed by Mamman Mohammed,  Director General, Press and Media Affairs to Yobe Governor, and made available to the News Agency of Nigeria (NAN) on Saturday in Damaturu.

Mohammed said Mr Bill Gates and Alh.  Aliko Dangote gave the commendation in separate remarks via virtual platform at the mid- year review meeting on the tripartite Memorandum of Understanding (MoU) for routine immunisation.

According to Gates, in spite of the challenges the state faces,  Yobe government has worked tirelessly in contributing to the polio-free status of Nigeria.

Gates urged Gov. Mai Mala Buni and other stakeholders to sustain the tempo in fighting the virus.

Similarly, the chairman of Dangote Foundation,  Alh. Dangote, commended Yobe  government for investing in the health sector to improve the health of the citizens.

In his remarks, Gov. Buni pledged the commitment of his administration to improving  the health of the people of the state.

“I want to assure you that Yobe  government will remain committed to providing effective, affordable and accessible healthcare services to the citizenry.

“We will continue to collaborate with our development partners to promote a healthy population in our state and the country,” he said.

The governor said in spite of substantial decline in revenue which necessitated the downward review of the state’s year  2020 budget by 20.4 per cent, the state had been able to fulfill its counterpart obligation as contained in the  MoU for Primary Healthcare Centre (PHC).

He said contract had been awarded for the supply of 60 customised tricycle ambulances that would be used in conveying expectant mothers to health facilities, adding that 28 similar tricycles purchased earlier for same purpose had yielded the desired result.

Buni also assured the commitment of the state government in providing a functional primary healthcare in each of the 178 political wards.

He assured of provision of  effective and efficient healthcare services through the newly introduced Contributory Healthcare Scheme.

NAN


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Podcast: Video: TWiV 661: SWAG with Ralph Baric | This Week in Virology.

[September 10, 2020]

Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich ConditKathy Spindler and Brianne Barker

Guest: Ralph Baric

Watch 'virtual roundtable'; discussion on YouTube video [2:00:40]: https://youtu.be/XyQ6fuCtg4A

or

Listen to Podcast via source article

or

Download TWiV 661 (70 MB .mp3, 116 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Links for this episode

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv


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The effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines | BMC Infectious Diseases.

[Open Access] [Received 18 February 2020; Accepted 16 August 2020; Published 31 August 2020]

Abstract.

Background.

Maternal poliovirus antibodies could provide passive immunity to the newborns from poliovirus infection during their first few months of life, but they may impair the immune responses of infants to the poliovirus vaccine as well. In our study, we pooled the data from three clinical trials of the inactivated poliovirus vaccine (IPV) based on Sabin strains to investigate the effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines.

Methods.

There were five groups in the pooled analysis, including low-dose Sabin IPV, medium-dose Sabin IPV, high-dose Sabin IPV, control Sabin IPV, and control Salk IPV groups. We reclassified the infants in different groups according to their maternal poliovirus antibodies by two methods, the first one included maternal antibody negative (< 1:8) and maternal antibody positive (≥1:8), and the second one included maternal antibody titer < 1:8, 1:8 ~ < 1:32 and ≥ 1:32. Then, we compared the geometric mean titers (GMTs), geometric mean antibody fold increases (GMIs) and seroconversion rates of poliovirus type-specific neutralizing antibodies after vaccination among participants with different maternal poliovirus antibody levels.

Results.

The GMTs and GMIs of three types of poliovirus antibodies after vaccination in maternal antibody negative participants were significantly higher than those in maternal antibody positive participants. The seroconversion rates of type II and type III poliovirus antibodies in maternal antibody positive participants were significantly lower than those in maternal antibody negative participants. Among participants with maternal antibody titer < 1:8, 1:8 ~ < 1:32 and ≥ 1:32, the GMTs and GMIs of three types of poliovirus antibodies after vaccination showed a tendency to decline with the increasing of maternal antibody levels. The seroconversion rates of three types of poliovirus antibodies in participants with maternal antibody titer ≥1:32 were significantly lower than those in participants with maternal antibody titer < 1:8 and 1:8 ~ < 1:32.

Conclusions.

Maternal poliovirus antibodies interfered with the immune responses of infants to poliovirus vaccines, and a high level of maternal antibodies exhibited a greater dampening effect.

Trial registration

ClinicalTrials.govNCT04264598 February 11, 2020; ClinicalTrials.govNCT04264546 February 11, 2020; ClinicalTrials.govNCT03902054 April 3, 2019. Retrospectively registered.


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The risk of unintentional propagation of poliovirus can be minimized by using human cell lines lacking the functional CD155 gene | Microbiology and Immunology.

[Pay to View Full Text] [Accepted manuscript online: 09 September 2020]

Abstract.

After eradication and containment of wild poliovirus (PV) and cessation of oral polio vaccinations, it is critical to minimize the risk of reintroducing PV into PV‐free communities via facilities that handle the virus. The potential risk of unintentional PV propagation through unidentified contaminated materials is a serious issue. This study reports the generation of HeLa and RD‐A cells deficient in functional CD155 gene (∆PVR cells); these cells are not susceptible to PV but remain susceptible to other picornaviruses. These ∆PVR cells will minimize the risk of unintentional transmission of PV and support performing the experiments more safely.


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