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CIMAF Ghana support Kpone Akatamanso health directorate in Polio immunisation exercise | Joy Online.

[7 October 2020 3:54pm]

Another strain of the virus that causes Polio or Paralyzes is spreading across 16 African countries including Ghana.

So far more than 170 children have been paralyzed between July 2019 and August 2020. Out of this figure, 31 is reported here in Ghana.

Producers of Cimaf Cement has partnered with the Health Directorate of Kpone Katamanso Municipality to immunise children in the catchment area which is also the operational location of the company.

As Ghana Health Service and teams of health volunteers prepare to immunize children under five years through a vaccination exercise from the 8th to 11th October against polio across Ghana, Staff of Cimaf is supporting this cause with cash to aid GHS and Its volunteers in the Kpone Katamanso Municipality in this exercise.

CMAF

Speaking to the media, The Director of Sales and Marketing, Mr Joseph Kobina Aboo said Cimaf have a responsibility to help people especially children in the area which they operate hence the acceptance to support this good cause.

The Municipal Health Director Dr Esther Priscilla Biama Dankwa urged parents to make available their children for this all important health exercise so that Africa can see an end to all types of polio.


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Immunogenicity of seasonal inactivated influenza and inactivated polio vaccines among children in Senegal: Results from a cluster-randomized trial | Vaccine.

[Pay to View Full Text] [Received 15 May 2020, Revised 25 August 2020, Accepted 20 September 2020, Available online 2 October 2020] [In Press, Corrected Proof]

Highlights.

* Influenza vaccine immunogenicity was assessed as part of a cluster-randomized trial.

* Children aged 6 months through 8 years in rural Senegal were enrolled.

* Inactivated influenza vaccines were immunogenic in Senegalese children.

* Seroconversion rates are higher for older children and with influenza A antigens.

* Antigenically naïve children have lower post-vaccine geometric mean titers.

Abstract.

Data on influenza vaccine immunogenicity in children are limited from tropical developing countries. We recently reported significant, moderate effectiveness of a trivalent inactivated influenza vaccine (IIV) in a controlled, cluster-randomized trial in children in rural Senegal during 2009, a year of H3N2 vaccine mismatch (NCT00893906). We report immunogenicity of IIV3 and inactivated polio vaccine (IPV) from that trial. We evaluated hemagglutination inhibition (HAI) and polio antibody titers in response to vaccination of three age groups (6 through 35 months, 3 through 5 years, and 6 through 8 years). As all children were IIV naïve, each received two vaccine doses, although titers were assessed after only the first dose for subjects aged 6 through 8 years. Seroconversion rates (4-fold titer rise or increase from <1:10 to ≥1:40) were 74–87% for A/H1N1, 76–87% for A/H3N2, and 54–79% for B/Yamagata. Seroprotection rates (HAI titer ≥ 1:40) were 79–88% for A/H1N1, 88–96% for A/H3N2, and 52–74% for B/Yamagata. IIV responses were lowest in the youngest age group, and they were comparable between ages 3 through 5 years after two doses and 6 through 8 years after one dose. We found that baseline seropositivity (HAI titer ≥ 1:10) was an effect modifier of IIV response. Using a seroprotective titer (HAI titer ≥ 1:160) recommended for IIV evaluation in children, we found that among subjects who were seropositive at baseline, 69% achieved seroprotection for both A/H1N1 and A/H3N2, while among those who were seronegative at baseline, seroprotection was achieved in 11% for A/H1N1 and 22% for A/H3N2. The IPV group had high baseline polio antibody seropositivity and appropriate responses to vaccination. Our data emphasize the importance of a two-dose IIV3 series in vaccine naïve children. IIV and IPV vaccines were immunogenic in Senegalese children.


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Differentiating Post-Polio Syndrome from Myalgic Encephalomyelitis and Chronic Fatigue Syndrome | Fatigue | PubMed Central.

[Open Access] [Fatigue. Author manuscript; available in PMC 2020 Oct 2.] [The publisher's final edited version of this article is available at Fatigue] [Published online 2019 Nov 6.]

Abstract.

Background.

Overlapping and concomitant symptoms among similar chronic illnesses have created difficulties for diagnosis and further treatment. Three such chronically fatiguing illnesses, Post-polio syndrome (PPS), Myalgic Encephalomyelitis (ME) and chronic fatigue syndrome (CFS) fall under this category.

Purpose.

The aim of this study is to examine and distinguish between core symptoms found in these illnesses (i.e. muscle pain/weakness, fatigue or exhaustion, and autonomic symptoms) via three methods of analysis (DePaul Symptom Questionnaire 2 (DSQ-2), Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and machine learning techniques).

Results.

Items assessing onset and severity for individuals who reported having PPS were found to have experienced an onset of PPS related symptoms roughly 30 years after the onset of Polio. Items found in the DSQ-2, SF-36 compared all illness groups and found that participants with ME/CFS were more functionally impaired across symptoms than those with PPS. Across all analyses, three domains most commonly differentiated the illnesses (neurocognitive, Post-exertional malaise, and neuroendocrine).

Conclusion.

Examining functional impairment amongst chronically fatiguing illnesses using multiple methods of analysis can be an important factor in distinguishing similar illnesses. These findings support further analysis of analogous symptomatology among other chronic illnesses to assist in diagnosis.


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Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient | Autophagy,

[Pay to View Full Text] [Received 08 May 2020, Accepted 24 Sep 2020, Accepted author version posted online: 05 Oct 2020] [Accepted author version]

Abstract.

Paralytic poliomyelitis is a rare disease manifestation following poliovirus (PV) infection. The disease determinants remain largely unknown. We used whole exome sequencing to uncover possible contributions of host genetics to the development of disease outcome in humans with poliomyelitis. We identified a patient with a variant in ATG7, an important regulatory gene in the macroautophagy/autophagy pathway. PV infection did not induce a prominent type I interferon response, but rather activated autophagy in neuronal-like cells, and this was essential for viral control. Importantly, virus-induced autophagy was impaired in patient fibroblasts and associated with increased viral burden and enhanced cell death following infection. Lack of ATG7 prevented control of infection in neuronal-like cells, and reconstitution of patient cells with wild-type ATG7 re-established autophagy-mediated control of infection. Collectively, these data suggest that ATG7 defect contributes to host susceptibility to PV infection and propose autophagy as an unappreciated antiviral effector in viral infection in humans.


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Art and Pediatric Orthopaedics: Sorolla and a Sad Inheritance | Journal of Pediatric Orthopaedics.

[Pay to View Full Text] [October 02, 2020 - Volume Publish Ahead of Print]

Abstract.

The Sad Inheritance painted by Sorolla depict children with polio. The clarity of the painting enables the viewer to identify gait abnormalities due to muscle paralysis.

Joaquin Sorolla Triste Herencia

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Public Domain Images available from:
File:Joaquin Sorolla Triste Herencia.jpg
https://commons.wikimedia.org/wiki/File:Joaquin_Sorolla_Triste_Herencia.jpg


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