New publication: Using SR methods to evaluate how well zebrafish embryotoxicity assays predict mammalian developmental toxicity

Although first developed to assess acute chemical toxicity in fish, it has been suggested that the zebrafish embryotoxicity test (ZET) may also be useful for predicting the developmental toxicity of chemicals in mammals. If true, this could lead to a reduction in use of mammals in toxicity testing. Many primary studies have investigated this issue, but until now this evidence has not been synthesised.

In this new paper by EBTC, we therefore systematically reviewed how well the ZET predicts prenatal development toxicity in rats and rabbits. You can read the full paper here (OA): https://doi.org/10.1093/toxsci/kfab072

Sign up! EBTC Online Scientific Symposium
10am-11:30am EST, Friday 25 June 2021

Overcoming data availability obstacles in the way of
evidence-based toxicology.

Click here to register.

This Symposium will discuss the issues of selective publishing and regulatory data gaps in toxicology, and how they might be addressed.

Agenda

1. Evidence-based assessment of three lines of evidence on drug-induced liver injury: main conclusions, limitations and barriers to implementation. Dr. Katya Tsaioun, EBTC

2. Gaps in preclinical and clinical data: a need for transparency in the regulatory evidence base. Dr Jan Turner, Safer Medicines Trust

3. AI-based data extraction and predictive toxicology – learning from use for chemical safety. Dr. Thomas Hartung, CAAT at Johns Hopkins School of Public Health

The paper on which the first presentation is based, on the extent to which drug-induced liver injury can be predicted from preclinical models, and therefore potentially be avoided in human populations, is available here (OA).

The Symposium will be held online at 10am-11:30am Eastern time, 3pm-4:30pm UK time, on Friday 25 June 2021. The Symposium is open to all. Click here to register.

Survey: What interests you in evidence-based toxicology, and what can EBTC do to help?

We are running a survey of the evidence-based toxicology community, to find out what you are interested in and how EBTC can help. 

Click here to take the survey. We look forward to hearing from you!