EBTC Newsletter | July 2019
In this newsletter (scroll down):
  • Systematic reviews of mechanistic evidence - a workshop
  • Editors meet to address quality of toxicology systematic reviews
  • EBTC speakers at National Academies of Sciences workshop
  • New publications, including evidence maps for risk assessment
  • Opportunity: EFSA CFP for problem formulation frameworks
  • EBTC organisational updates
Participants in the EBTC/GRADE mechanistic frameworks workshop, June 12

EBTC and GRADE Working Group workshop on mechanistic frameworks for alternative test methods

June 12, Hamilton ON. EBTC and the international GRADE Working Group collaborated on a workshop “Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests.”

The workshop brought together international regulatory bodies (US EPA, EFSA, OECD, NIEHS, risk assessors, academic scientists, and industry) to explore, via discussion of related themes, how systematic review methods and AOP concepts can be combined to develop and use non-animal test methods for predicting the toxicity of chemical substances in an evidence-based manner.

The proceedings of the workshop will be published shortly. The video of the workshop presentations and plenary discussions can be viewed here.

Assuring the Standard of Systematic Reviews in Toxicology: A Workshop for Journal Editors

May 29-31, Research Triangle Park, NC. Supported by t4 (the Transatlantic Think Tank for Toxicology), this first-of-its-kind EBTC workshop brought together journal editors, systematic review experts, and experts in scientific publishing processes, to develop a joint strategy which will assure the quality of systematic reviews being published in toxicology and environmental health journals.

Workshop outputs include: proceedings (to be published in ALTEX); a joint statement across multiple titles on new minimum expectations for systematic reviews to be published in environmental health journals; and a white paper on the long-term strategic role of journals and editors in raising publishing standards for SRs in the environmental health field. These will be developed over the next 6-12 months.

Anyone interested in more information should contact Paul Whaley, EBTC Research Fellow and coordinator of the Editors Workshop.

Editors workshop participants choose their favoured editorial interventions for ensuring published SRs are of high quality.

National Academies Workshop on Integrating In Vitro Evidence into the Risk Assessment

June 3-4, 2019, Washington DC. EBTC Director Katya Tsaioun served on the organizing committee of the US National Academies of Sciences series of workshops on integrating mechanistic / in vitro evidence into the risk assessment. The agenda, video of presentations, and presentation slideshows, can be viewed here (PDF). Presentations by EBTC affiliated researchers included:

New publications

Papers by EBTC staff and our partner organisations

Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity Test. M. Stephens, S. Gül Akgün-Ölmez, S. Hoffmann, R. de Vries, B. Flick, T. Hartung, M. Lalu, A. Maertens, H. Witters, R. Wright, K. Tsaioun. Toxicological Sciences, June 16, 2019.
Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management. T. Wolffe, P. Whaley, C. Halsall, A.Rooney, V. Walker. Environment International, Volume 130, Sept. 2019, 104871

Toward Good In Vitro Reporting Standards. T. Hartung, R. de Vries, S. Hoffmann, H. Hogberg, L. Smirnova, K. Tsaioun, P. Whaley, M. Leist. 2019. ALTEX 36 (1): 3-17.
Software tools for literature screening in systematic reviews in biomedical research. S. van der Mierden, K. Tsaioun, A. Bleich, C. Leenaars. 2019. ALTEX. doi:10.14573/altex.1902131.

Funding opportunity

The European Food Safety Authority has issued a tender for proposals to "develop a standardised approach for problem formulation as first step of the food and feed safety scientific assessment process". More information is available here. Deadline is 30 August 2019.

EBTC Organizational news

EBTC welcomes Dr Yvonne Will to EBTC Board of Trustees. Dr Yvonne Will is a biochemist with 20 years’ experience in biotech and large pharma. Dr Will’s expertise is diverse and spans a wide range of drug discovery skills, such as discovery biology, chemistry, discovery toxicology and technology implementation. Dr Will received the Connecticut Women in Innovation and Leadership Award (2013) and is a Fellow of the Academy of Toxicological Sciences (2015).

What's coming

As you can see from the above list, EBTC has been quite busy in the past months, and fell off our schedule of newsletters, so apologies for this newsletter being too long. We also had some good news  for 2020 from SOT, EUROTOX and AAAS, so stay tuned for announcements of the workshops and symposia we are are putting together at these major events.
The Evidence-Based Toxicology Collaboration is an open international network of academic, government, non-profit and industry organizations, formed to foster collaborative development and adoption of evidence-based methodologies in toxicology. The EBTC is governed by the Board of Trustees.
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