COVID-19 Evidence alert - 7th August 2020
COVID-19 Evidence alert is a weekly update highlighting emerging evidence on the following key topics identified as useful in supporting Covid recovery planning:
  1. Residential settings
  2. Impacts of lifting restrictions
  3. Long term rehabilitation needs
  4. Screening and testing
  5. Broader impacts on health outcomes
  6. Impact on non-Covid care
This update follows on from a series of rapid evidence scans on these key topics, with corresponding evidence trackers providing details of relevant papers. 

The evidence scans and corresponding evidence trackers can be found here: (see ‘Evidence - Helping you to keep up to date’).

Here you will also find details of the evidence that has been used to inform this weekly update.

We are also working on other key areas of interest such as impacts on inequalities and marginalised groups, which will be added to the alert once completed.

Please note that this email alert excludes section summaries due to the breadth and volume of evidence covered in the alert.

Analytical Collaboration for COVID-19  

As previously described the collaboration are supporting ad hoc immediate questions raised by national bodies but are also using their expertise to focus on questions that the NHS may lack the immediate resources to look at, which may be more medium-term, cut across sectors, or benefit from independent analysis. 

Residential facilities

Coronavirus (COVID-19): admission and care of people in care homes. Department of Health and Social Care, Care Quality Commission, Public Health England & NHS England. (last updated 31/7/20).

Rapid reviews
Updated findings: Living systematic review of emerging evidence on COVID-19 related mortality and spread of disease in Long-Term Care (31 July 2020). Salcher-Konrad M et al., LTCCovid.

Emerging evidence
Increased risk of SARS-CoV-2 infection in staff working across different care homes enhanced Covid-19 outbreak investigations in London care homes. Ladhani SN et al., Journal of infection.

Expanding frontiers of risk management: care safety in nursing home during COVID-19 pandemic. Scopetti M et al., Int J Quality Health Care.

COVID-19 Collaborative Model for an Academic Hospital and Long-Term Care Facilities. Archbald-Pannone LR et al., Journal of Post-Acute and Long-Term Care Medicine.

COVID-19 and Long-Term Care in the US State of Minnesota. Arling G & Arling P. LTC Policy Network. (last updated 27/7/20).

Impacts of lifting restrictions

Emerging evidence
Determining the optimal strategy for reopening schools, the impact of test and trace interventions, and the risk of occurrence of a second COVID-19 epidemic wave in the UK: a modelling study. Panovska-Griffiths J et al., The Lancet Child & Adolescent Health.

Transient dynamics of SARS-CoV-2 as England exited national lockdown. Riley S et al., medRxiv (preprint).

The COVID-19 pandemic: diverse contexts; different epidemics—how and why? Van Damme W et al., BMJ Global Health.

Locked down leisure in Britain. Roberts K. Leisure Studies.

Physical distancing worked to combat the spread of Covid-19 Using Google Mobility data. O’Connor KJ. Economie Et Statistiques Working Papers Du Statec.

COVID-19 lockdowns cause global air pollution declines. Venter ZS et al., PNAS.

The impact of COVID-19 on public space: an early review of the emerging questions – design, perceptions and inequities. Honey-Rosés J et al., Cities & Health.

Lockdown urbanism: COVID-19 lifestyles and liveable futures opportunities in Wuhan and Manchester. Jefferies T et al., Cities & Health.

The United Kingdom’s Coronavirus Act, deprivations of liberty, and the right to liberty and security of the person. Pugh J. Journal of Law and the Biosciences, 7(1).

Social distancing responses to COVID-19 emergency declarations strongly differentiated by income. Weill JA et al., Economic Sciences.

How Parents and Their Children Used Social Media and Technology at the Beginning of the COVID-19 Pandemic and Associations with Anxiety. Drouin M et al., Cyberpsychology, Behaviour, and Social Networking.

How communication technology helps mitigating the impact of COVID-19 pandemic on individual and social wellbeing: Preliminary support for a compensatory social interaction model. Canale N et al., PsyArXiv. (pre-print).

Long term rehabilitation needs

Rapid reviews
Systematic review of changes and recovery in physical function and fitness following Severe Acute Respiratory Syndrome-related Coronavirus (SARS-CoV) infection: Implications for COVID-19 rehabilitation. Rooney S et al., Physical Therapy, pzaa129. (Uncorrected Manuscript).

Emerging evidence
Impacts of Covid-19 on the immune, neuromuscular, and musculoskeletal systems and rehabilitation. D’Andréa Greve JM et al., Rev Bras Med Esporte.

Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors. Mazza MG et al., Brain, Behavior, and Immunity.

Post-discharge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation. Halpin SJ et al., Journal of Medical Virology.

Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020. Tenforde MW et al., MWWR Morbidity and Mortality Weekly Report.

Why Rehabilitation must have priority during and after the COVID-19-pandemic: A position statement of the Global Rehabilitation Alliance. Gutenbrunner C et al., J Rehabil Med.

COVID-19 “Long Hauler” Symptoms Survey Report. Lambert NJ & Survivor Corps. Indiana University. (non-peer reviewed).

COVID-19 Guide for the Rehabilitation Clinician. A Review of Nonpulmonary Manifestations and Complications. Lopez M et al., Am J Phys Med Rehab.

From ‘brain fog’ to heart damage, COVID-19’s lingering problems alarm scientists. Couzin-Frankel J. Science. (published online 31/7/20).

What exactly is mild covid-19? Alwan NA. BMJ Opinion. (published online 28/7/20).

Persistent self-reported changes in hearing and tinnitus in post-hospitalisation COVID-19 cases. Munro KJ et al., Int J Audiology. (published online 31/7/20).

Useful resources
Supporting your recovery after COVID-19. Singh S et al., YourCovidRecovery.NHS.UK.

Screening and testing

Use of Chest Imaging in the Diagnosis and Management of COVID-19: a WHO Rapid Advice Guide. Akl EA et al., WHO.

Emerging evidence
Weekly COVID-19 testing with household quarantine and contact tracing is feasible and would probably end the epidemic. Peto J et al., Royal Society Open Science.

Universal screening for SARS-CoV-2 in pregnant women at term admitted to an East London maternity unit. Abeysuriya S et al., European Journal of Obstetrics & Gynaecology and Reproductive Biology.

Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study. Nguyen LH et al., The Lancet Public Health.

Characteristics and transmission dynamics of COVID-19 in healthcare workers at a London teaching hospital. Zheng C et al., Journal of Hospital Infection.

Olfactory and taste disorders in healthcare workers with COVID-19 infection. Villarreal IM et al., European Archives of Oto-Rhino-Laryngology.

COVID-19 or common coronavirus? A cautionary tale in advanced diagnostics. Howard-Anderson J et al., Diagnosis.

COVID cases in England aren’t rising: here’s why. Heneghan C. Oxford CEBM. (published online 2/8/20).

Covid-19: Sandwell Council in West Midlands sets up contact tracing, citing failures of national scheme. Limb M. BMJ, 370:m3065. (published online 31/7/20).

Broader impacts on health outcomes

Commentary from the collaboration
Emerging evidence of COVID-19’s unequal mental health impacts on health and social care staff. Kwong E & Marshall L. The Health Foundation. (published online 31/7/20).

Emerging evidence on health inequalities and COVID-19: July 2020. Leavey C et al., The Health Foundation. (published online 4/8/20).

London Covid-19 Dialogue & Deliberation. Interim Report- early insights from a Dialogue with Londoners. Imperial College Health Partners and Ipsos MORI. (published online June 2020).

Meeting the psychological needs of children in shielding families. British Psychological Society. (published July 2020).

Rapid reviews
Mental health- general public
Prevalence of posttraumatic and general psychological stress during COVID-19: A rapid review and meta-analysis. Cooke JE et al., Psychiatry Research.

Emerging evidence
Public health
Coronavirus and the social impacts on Great Britain: 31 July 2020. Davies R. Office for National Statistics.

Understanding grief in a time of COVID-19 - a hypothetical approach to challenges and support. Fang C & Comery A. Advance (pre-print).

Life on Hold. Children’s Well-being and COVID-19. The Children’s Society. (published online July 2020).

Mental health- general public
Coping and Tolerance of Uncertainty: Predictors and Mediators of Mental Health During the COVID-19 Pandemic. Rettie H & Daniels J. American Psychologist.

Social capital and mental health during the COVID-19 pandemic. Rodela TT et al., SocArXiv. (pre-print).

Pre-existing conditions
Understanding the experiences of people who inject drugs during the COVID-19 pandemic: Interim report 3. Hines LA et al., University of Bristol.

How is COVID-19 Affecting the Mental Health of Children with Special Educational Needs and Disabilities and Their Families? Asbury K et al., J Autism Dev Disord.

Caregivers’ Mental Health and Somatic Symptoms During Covid-19. Park SS. The Journals of Gerontology.

Public health
Behavioural, environmental, social, and systems interventions against covid-19. Michie S & West R. BMJ,370:m2982. (published online 28/7/20).

Infectious Disease Outbreak Related Stigma and Discrimination during the COVID-19 Pandemic: Drivers, Facilitators, Manifestations, and Outcomes across the World. Ransing R et al., Brain Behav Immun. (published online 27/7/20).

Mental health
Suicide Research, Prevention, and COVID-19. Towards a Global Response and the Establishment of an International Research Collaboration. Niederkrotenthaler T et al., Crisis. (published online 27/7/20)

COVID-19 and the Management of Chronic Mental Illnesses. Javed A & Afzal M. J Psychosoc Rehabil Ment Health. (published online July 2020).

COVID-19: The Hidden Impact on Mental Health and Drug Addiction. Chiappini S et al., Frontiers in Psychiatry. (published online 29/7/20).

Useful resources
Creating Wellness in a Pandemic: A Practical Framework for Health Systems Responding to Covid-19. Adibe B et al., NEJM Catal Innov Care Deliv.

Remotely Delivered Cognitive Behavior Therapy for Disturbed Grief During the COVID-19 Crisis: Challenges and Opportunities. Boelen PA et al., Journal of Loss and Trauma. (published online 31/7/20).

Impact on non-Covid care

Commentary from the collaboration
How might COVID-19 affect the number of GPs available to see patients in England? Fisher R & Asaria M. The Health Foundation. (published online 6/8/20).

Technology and innovation for long-term health conditions. Collins B. The King’s Fund. (published online August 2020).

Third phase of NHS response to COVID-19. NHS England. (published online 31/7/20).
Readying the NHS and social care for the COVID-19 peak. House of Commons Public Accounts Committee. (published online 20/7/20).

Restarting gastrointestinal endoscopy in the deceleration and early recovery phases of COVID-19 pandemic: Guidance from the British Society of Gastroenterology. Rees CJ et al., Clinical Medicine.

Psychological insights for cancer services recovery planning. British Psychological Society & Division of Clinical Psychology- Faculty for Oncology & Palliative Care. (published online July 2020).

Emerging evidence
Resilient Health and Care. Learning the lessons of COVID-19 in the English NHS. Thomas C. Institute for Public Policy Research. (published online July 2020).

Data-informed recommendations for services providers working with vulnerable children and families during the COVID-19 pandemic. Wilke NG et al., Child Abuse & Neglect.

Primary care
The impact of COVID-19 restrictions on needle and syringe programme provision and coverage in England. Whitfield M et al., Int J Drug Policy.

COVID-19 and reproductive justice in Great Britain and the United States: ensuring access to abortion care during a global pandemic. Romanis EC et al., Journal of Law and the Bioscience, 7(1).

Elective care
Is a “COVID-19-free” hospital the answer to resuming elective surgery during the current pandemic? Results from the first available prospective study. Gammeri E et al., Surgery.

Safety evaluation of a strategy to restart elective orthopaedic surgery during the de-escalation phase of the COVID-19 pandemic. Zahra W et al., Bone Joint Open.

Secondary care
COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England.  Mafham MF et al., The Lancet, 396 (10248), 381-9.

Impact of COVID-19 on diagnosis and management of paediatric inflammatory bowel disease during lockdown: a UK nationwide study. Ashton JJ et al., Arch Disease Childhood.

The impact of COVID-19 on the future of orthopaedic training in the UK. Dattani R et al., Acta Orthopaedica.

Tertiary care
Initial changes in neuropsychologists clinical practice during the COVID-19 pandemic: a survey study. Marra DE et al., The Clinical Neuropsychologist.

Cancer care
Cancer Research UK Cancer Patient Experience Survey 2020. The impact of COVID-19 on cancer patients in the UK. Ide C et al., CRUK.

Roadmap to strengthen global mental health systems to tackle the impact of the COVID-19 pandemic. Maulik PK et al., Int J Mental Health Systems. (published online 29/7/20).

U.K. Response to the COVID-19 Pandemic: Managing Plastic Surgery Patients Safely. Reissis D et al., Plastic and Reconstructive Surgery. (published online August 2020).

Useful resources
The impact of COVID-19 on community health services. NHS Confederation. (published online 4/8/20).

Five principles for the next phase of the Covid-19 response. National Voices. (published online June 2020).

Revisiting health information technology ethical, legal, and social issues and evaluation: telehealth/telemedicine and Covid-19. Kaplan B. In J Med Informatics.

Telemedicine for preoperative assessment during a COVID-19 pandemic: Recommendations for clinical care. Mihalj M et al., Best Pract Res Clin Anaesthisiol.

This update forms part of a national evidence update service, provided by the Strategy Unit, as part of a collaboration to provide analytical support to the health and care system to help in the fight against COVID-19. For more information, visit: or 
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